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scd1 inhibitor a939572  (TargetMol)


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    Structured Review

    TargetMol scd1 inhibitor a939572
    Scd1 Inhibitor A939572, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/scd1+inhibitor+a939572/A939572/10__7150_slash_ijbs__126269-71-1-5
    Average 94 stars, based on 7 article reviews
    scd1 inhibitor a939572 - by Bioz Stars, 2026-09
    94/100 stars

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    Related Articles

    Lactate Dehydrogenase Assay:

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Western Blot:

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Irradiation:

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Plasmid Preparation:

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Transfection:

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    shRNA:

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    In Vivo:

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Injection:

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Staining:

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Cell Characterization:

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Quantitative RT-PCR:

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Expressing:

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Co-Immunoprecipitation Assay:

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Ubiquitin Proteomics:

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Control:

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Immunofluorescence:

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Liquid Chromatography with Mass Spectroscopy:

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Activity Assay:

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Binding Assay:

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Mutagenesis:

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Construct:

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.

    Article Title: Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
    Article Snippet: For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).For pharmacological interventions, tyrosol (188255, Sigma) was dissolved in saline and administered orally at 20, 50 or 75 mg/kg daily in a volume of 75-100 μL (not exceeding 5 mL/kg).. The SCD1 inhibitor A939572 (T4515, TargetMol) was dissolved in dimethyl sulfoxide as a 150 mg/mL stock.. The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.The mice were administered A939572 daily by oral gavage (30 mg/kg diluted in corn oil) at 3 days before tyrosol treatment.



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    Image Search Results


    Membrane lipid saturation-induced UPR was suppressed in UGT8 KO HeLa cells. (A) Immunofluorescence of HeLa cells transiently expressing C-terminal FLAG-tagged mUgt8. Cells were immunostained with indicated antibodies. Scale bar, 10 μm. (B, C) The mRNA level of CHOP in WT or UGT8 KO (#1) HeLa cells treated with SCD1 inhibitor (100 nM) for 24 h (B) or tunicamycin (2.5 μg/ml) for 6 h (C) was quantified using qRT-PCR ( n = 3). (D–G) PERK phosphorylation of WT or UGT8 KO (#1) HeLa cells treated with SCD1 inhibitor (100 nM) for 24 h (D, E) or tunicamycin (2.5 μg/ml) for 6 h (F, G) were evaluated using immunoblotting (representative data of n = 2 out of n = 3 independent experiments). The ratio of phosphorylated PERK (pPERK) to total PERK was quantified (E, G) ( n = 3). (H–J) WT, UGT8 KO (#1) and UGT8 KO (#1) stably expressing mUgt8(WT)-FLAG or mUgt8(H358A)-FLAG HeLa cells were treated with SCD1 inhibitor (100 nM) for 24 h. PERK phosphorylation was evaluated using immunoblotting (F) (representative data of n = 2 out of n = 3 independent experiments). The ratio of phosphorylated PERK (pPERK) to total PERK was quantified (I) ( n = 3). The mRNA level of CHOP was quantified using qRT-PCR (J) ( n = 3). Mean ± SD. * P < 0.05, *** P < 0.001, **** P < 0.0001, ns; not significant, two-tailed unpaired t -test (B, C, E, G), one-way ANOVA with Dunnett’s multiple comparisons test (I, J).

    Journal: Journal of Biochemistry

    Article Title: Characterization of UGT8 as a monogalactosyl diacylglycerol synthase in mammals

    doi: 10.1093/jb/mvae084

    Figure Lengend Snippet: Membrane lipid saturation-induced UPR was suppressed in UGT8 KO HeLa cells. (A) Immunofluorescence of HeLa cells transiently expressing C-terminal FLAG-tagged mUgt8. Cells were immunostained with indicated antibodies. Scale bar, 10 μm. (B, C) The mRNA level of CHOP in WT or UGT8 KO (#1) HeLa cells treated with SCD1 inhibitor (100 nM) for 24 h (B) or tunicamycin (2.5 μg/ml) for 6 h (C) was quantified using qRT-PCR ( n = 3). (D–G) PERK phosphorylation of WT or UGT8 KO (#1) HeLa cells treated with SCD1 inhibitor (100 nM) for 24 h (D, E) or tunicamycin (2.5 μg/ml) for 6 h (F, G) were evaluated using immunoblotting (representative data of n = 2 out of n = 3 independent experiments). The ratio of phosphorylated PERK (pPERK) to total PERK was quantified (E, G) ( n = 3). (H–J) WT, UGT8 KO (#1) and UGT8 KO (#1) stably expressing mUgt8(WT)-FLAG or mUgt8(H358A)-FLAG HeLa cells were treated with SCD1 inhibitor (100 nM) for 24 h. PERK phosphorylation was evaluated using immunoblotting (F) (representative data of n = 2 out of n = 3 independent experiments). The ratio of phosphorylated PERK (pPERK) to total PERK was quantified (I) ( n = 3). The mRNA level of CHOP was quantified using qRT-PCR (J) ( n = 3). Mean ± SD. * P < 0.05, *** P < 0.001, **** P < 0.0001, ns; not significant, two-tailed unpaired t -test (B, C, E, G), one-way ANOVA with Dunnett’s multiple comparisons test (I, J).

    Article Snippet: The UGT8 inhibitor (compound 19) and SCD1 inhibitor (A939572) were purchased from Cayman Chemicals.

    Techniques: Membrane, Immunofluorescence, Expressing, Quantitative RT-PCR, Phospho-proteomics, Western Blot, Stable Transfection, Two Tailed Test